Background: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of\nirregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid\nformation. To date, there are no studies of keloids in Syria, and limited studies on Caucasians, so we have investigated\nthe risk factors of keloids in Syrians (Caucasians), and this is the main objective of this study.\nMethods: Diagnosis of keloids was clinically made after an interview and physical examination. We did a histopathological\nstudy in case the physical examination was unclear.\nThe following information was taken for each patient; sex, Blood groups (ABO\\Rh), cause of scarring, anatomical\nsites, age of onset, number of injured sites (single\\multiple) and family history.\nResults: We have studied the clinical characteristics of 259 patients with keloids,130 (50.2 %) females and 129 (49.8 %)\nmales. There were 209 (80.7 %) patients with keloids in a single anatomical site compared to 50 (19.3 %) patients with\n130 keloids in multiple anatomical sites, 253 (97.68 %) patients with keloids caused by a single cause for each patient\ncompared to 6 (2.32 %) patients with keloids caused by two different causes for each patient.\nKeloids could follow any form of skin injury, but burn was the most common (28.68 %). Also, keloids could develop at\nany anatomical sites, but upper limb (20 %) followed by sternum (19.17 %) was the most common. Over half\nof the patients developed keloids in the 11ââ?¬â??30 age range. 19.3 % (50/259) of patients had family history, 76 % (38/50)\nof them had keloids located in the same anatomical sites of relative, also, 66 % (33\\50) of them had keloids caused by\nthe same cause.\nThe following information was found to be statistically significant; people with blood group A (p = 0.01) compared\nwith other blood groups, spontaneous keloids in patients with blood group A (p = 0.01), acne in males (p = 0.0008)\ncompared to females, acne in someone who has a previous acne keloid (p = 0.0002), burn in someone who has a\nprevious burn keloid (p = 0.029), family history, especially for spontaneous (p = 0.005), presternal (p = 0.039) and\nshoulder (p = 0.008) keloids, people in second and third decades (p = 0.02) (p = 0.01) respectively.\nConclusion: Age of onset, sex, cause of scarring, blood groups, anatomical site, presence of family history and\nthe number of site (multiple\\single) were significant in keloid formation in Syrians.
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